ABTC Active Protocols

Recurrent Disease


MLN0128 (ABTC1301):

A Pilot Study of MLN0128 in Preoperative Recurrent Glioblastoma (GBM) Patients


Lapatinib (ABTC1302):

A Dug Distribution and Pharmacodynamic Study of Pulsatile Lapatinib in Srugically Accessible EGFR-Amplified Recurrent High-Grade Glioma Patients

TRC102 (ABTC1402):

A Phase II Study of TRC102 in Combination with Temozolomide for Recurrent Glioblastoma


Checkpoint Inhibitors (ABTC1501):

A Phase I Trial of Anti-LAG-3 or Anti-CD137 Alone and in Combination with Anti-PD-1 in Patients with Recurrent GBM



Newly-Diagnosed Disease


MK-1775 (ABTC1202):

A Phase I Study of MK-1775 with Radiation and Temozolomide in Patients with Newly Diagnosed Glioblastoma and Evaluation of Intratumoral Drug Distribution in Patients with Recurrent Glioblastoma.


IL-7 (ABTC1403):

A Study on the Effect of IL-7 (CYT107) CD4 Counts in Patients with High Grade Gliomas and Severe Treatment-Related CD4 Lymphopenia after Concurrent Radiation and Temozolomide